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Table 2 Pfmdr1 and pfcrt genotypes and MS markers flanking pfcrt in Plasmodium falciparum samples collected from Tafea Province, Vanuatu and Temotu and Malaita Provinces, Solomon Islands compared to reference samples

From: Genetic mutations in pfcrt and pfmdr1 at the time of artemisinin combination therapy introduction in South Pacific islands of Vanuatu and Solomon Islands

Origin (no. isolates)

n

H

%

MSamarker size (bp)

AA positions in Pfcrtb

MScmarker size (bp)

AA positions in Pfmdr1d

B5M77

2E10

PE12A

2H4

PE14F

Vanuatu Tafea (n = 17)

5

1

29.4

147

174

S MNT HALS QDL R

328

184

142

Y YC ND

1

1

5.9

147

174

S MNT HALS QDLI

314

184

142

Y YC ND

1

 

5.9

*

*

S MNT HALS*** R

*

*

*

Y YC ND

2

2

11.7

157

156

S MNT HALSE*TI

*

201

148

YF* ND

5

 

29.4

*

*

S MNT HALS**TI

*

*

*

Y YC ND

1

 

5.9

*

*

S MNT HALS**T R

*

*

*

Y YC ND

1

 

5.9

*

*

S MNT HALS*ST R

*

*

*

Y YC ND

1

 

5.9

*

*

CIET HALSE*T R

*

*

*

Y YC ND

Solomon Islands Temotu (n = 50)

23

3

64.7

149

174

S MNT HALS QDL R

328

192

139

Y YC ND

4

4

8.9

149

174

S MNT HALS QDL R

328

184

134

Y YC ND

1

4

2.9

149

174

S MNT HALS QDL R

328

184

136

Y YC ND

1

4

2.9

149

174

S MNT HALS QDL R

328

184

142

Y YC ND

1

 

2.9

*

*

S MNT HALS QDL R

*

*

*

Y YC ND

1

4

33.3

149

174

S MNT HALS QDT R

328

184

134

Y YC ND

1

 

2.9

*

*

S MNT HALS QDT R

*

*

*

**C ND

7

 

5.9

*

*

SMNT HALS QSTI

*

*

*

**C ND

2

 

5.9

*

*

SMNT HALS Q*TI

*

*

*

**C ND

1

5

2.9

140

166

CMNKHALS QNIR

314

184

148

**C ND

2

3

28.5

149

174

S MNT HALS QDL R

328

192

139

Y YC ND

1

3

14.2

149

174

S MNT HALS QDLI

328

192

139

Y YC ND

1

 

14.2

*

*

S MNT HALS QDL R

*

*

*

Y YC ND

1

 

16.7

*

*

S MNT HALS QSL R

*

*

*

**C ND

1

 

14.2

*

*

S MNT HAL**ST R

*

*

*

Y YC ND

1

 

14.2

*

*

S MNT HAL**STI

*

*

*

Y YC ND

1

 

14.2

*

*

S MNT H**A**T R

*

*

*

**C ND

Solomon Islands Malaita (n = 31)

9

3

29

149

174

S MNT HALS QDL R

328

192

139

Y YC ND

11

3

35.5

149

174

S MNT HALS QDLI

260

192

139

Y YC ND

4

4

12.9

149

174

S MNT HALS*** R

328

184

145

Y YC ND

1

6

3.2

149

154

S MNT HALSE*TI

328

192

142

Y YC ND

3

1

9.7

147

174

S MNT HALS**TI

328

184

142

Y YC ND

3

 

9.7

*

*

S MNT HALS**T R

*

*

*

Y YC ND

World reference Samples

Brazil 7G8

151

190

S MNT HALS QDL R

314

194

142

 

Philippines PH1

149

182

CMNT HTY AQDL R

314

228

136

 

Thailand Dd2

149

170

CIET HALSESTI

314

204

145

 

Thailand C2B

149

170

CIET HALSESTI

314

184

148

 

Solomon Island N18

149

174

S MNT HALS QDL R

328

184

142

 

PNG AN001

149

174

S MNT HALS QDL R

328

184

142

 

PNG AN018

149

174

S MNT HALS QDL R

328

192

139

 
  1. Note: Boldface amino acids represent the mutated state of that codon.
  2. aMS microsatellite upstream of pfcrt:B5M77 (-20 kb) and 2E10 (-5 kb).
  3. bAmino acid (AA) positions in pfcrt are 72, 74, 75, 76, 97, 144, 160, 220, 271, 326, 356, 371.
  4. cMS microsatellite downstream of pfcrt: PE12A (+6 kb), 2H4 (+22 kb) and PE14F (+106 kb).
  5. dAmino acid positions in pfmdr1 are 86, 184, 1034, 1042, 1246.
  6. *not determined.
  7. ** or *** indicates 2 or 3 AA positions were not determined