Enantiomerically pure amino-alcohol quinolines: in vitro anti-malarial activity in combination with dihydroartemisinin, cytotoxicity and in vivo efficacy in a Plasmodium berghei mouse model

Table 1 Susceptibility and geographical origin of the Plasmodium falciparum strains and clones used in this study

Strain/Clone	Geographical origin	Chloroquine susceptibility	Mefloquine susceptibility
K1	Thailand	R^a	S
W2	Indochina	R	S
FCM29	Cameroon	R	S
3D7	From NF54 African strain (MR4: Malaria Research and Reference Reagent Resource centre)	S	R
HB3	Honduras	S	R
BRE1	Brazil	R	R
Dd2	Indochina (from W2 strain)	R	R

^a:Parasites were considered resistant (R) if their IC₅₀ was higher than 100 nM for chloroquine and 50 nM for mefloquine.

ISSN: 1475-2875