Table 2 IC 50 s expressed as average (CV%) for CQ, MQ, ( S )-pentyl and ( S )-heptyl derivatives on the selected Plasmodium falciparum strains and clones
IC50(nmol L−1) | Ratio | |||||
|---|---|---|---|---|---|---|
Strain/Clone | CQ | MQ | S-pentyl | S-heptyl | MQ/( S)-pentyl | CQ/( S)-pentyl |
K1 | 164 (35.1) | 14.3 (28.0) | 4.1 (21.0) | NDa | 3.5 | 40.0 |
W2 | 572 (19.5) | 26.5 (9.2) | 7.0 (8.9) | 9.4 (9.7) | 3.8 | 81.7 |
FCM29 | 738 (7.2) | 24.5 (10.1) | 3.7 (10.5) | ND | 6.6 | 199.6 |
3D7 | 21.2 (13.7) | 67.0 (5.89) | 12.8 (3.1) | 14.5 (8.5) | 5.3 | 1.7 |
BRE1 | 265 (33.0) | 72.3 (10.4) | 11.7 (6.9) | ND | 6.2 | 22.6 |
Dd2 | 169 (20.4) | 84.7 (7.8) | 5.5 (19.3) | ND | 15.9 | 30.7 |
HB3 | 13.8 (20.5) | 98.7 (9.8) | 13.9 (7.4) | ND | 7.1 | 1.0 |