Table 1 Mouse causal prophylaxis experiments
DRUG (SC or PO) | Dose (mg/kg/day) | No. inoculated | No. 100% protected | Day of parasitaemia | Exp# |
|---|---|---|---|---|---|
None | 0.00 | 35 | 0 | 4-to-5 | 179 |
Clindamycin (SC) | 10.00 | 5 | 0 | 6-to-7 | 179 |
40.00 | 5 | 3 | 10,10 | 179 | |
Mirincamycin (racemate: 65% trans) (SC) | 1.10 | 5 | 3 | 10,10 | 180 |
3.30 | 5 | 5 | na | 180 | |
cis-Mirincamycin (SC) | 1.10 | 5 | 5 | na | 180 |
3.30 | 5 | 5 | na | 180 | |
trans-Mirincamycin (SC) | 1.10 | 5 | 3 | 10,10 | 179 |
3.30 | 5 | 5 | na | 179 | |
Lincomycin (SC) | 1.1-to-40 | 5 | 0 | 4-to-5 | 200 |
cis-Mirincamycin (SC) | 0.14 | 5 | 0 | 5-to-6 | 204 |
0.28 | 5 | 0 | 6-to-8 | 204 | |
0.55 | 5 | 3 | 7,9 | 204 | |
1.10 | 5 | 4 | 7 | 204 | |
cis-Mirincamycin (SC) | 0.14 | 5 | 0 | 4-to-6 | 205 |
0.28 | 5 | 0 | 6-to-8 | 205 | |
0.55 | 5 | 0 | 7-to-10 | 205 | |
1.10 | 5 | 3 | 10,10 | 205 | |
Mirincamycin (racemate: 65% trans) (PO) | 1.10 | 5 | 0 | 7-to-9 | 208 |
3.30 | 5 | 3 | 7-to-8 | 208 | |
10.00 | 5 | 5 | na | 208 | |
40.00 | 5 | 5 | na | 208 | |
cis-Mirincamycin (PO) | 1.10 | 5 | 0 | 7-to-8 | 208 |
3.30 | 5 | 5 | na | 208 | |
10.00 | 5 | 3 | 7-to-8 | 208 | |
40.00 | 5 | 5 | na | 208 | |
cis-Mirincamycin (PO) | 2 | 5 | 1 | 7--11 | 234 |
3.3 | 5 | 5 | na | 234 | |
10 | 5 | 5 | na | 234 | |
trans-Mirincamycin (PO) | 1.10 | 5 | 0 | 7 | 206 |
3.30 | 5 | 5 | na | 206 | |
10.00 | 5 | 5 | na | 206 | |
40.00 | 5 | 5 | na | 206 | |
trans-Mirincamycin (PO) | 2 | 5 | 2 | 7--8 | 234 |
3.3 | 5 | 4 | 10 | 234 | |
10 | 5 | 5 | na | 234 |