Table 1 Activity of tigecycline and tetracycline antibiotics against chloroquine-susceptible and -resistant strains of Plasmodium falciparum
Time (hours) | TigecyclineIC50(μM) | TetracyclineIC50(μM) | MinocyclineIC50(μM) | ChloroquineIC50(nM) | ||||
|---|---|---|---|---|---|---|---|---|
D6 | W2 | D6 | W2 | D6 | W2 | D6 | W2 | |
48 | >100 | 79.7 ± 20.1 | >100 | >100 | 56.7 ± 5.7 | 40.5 ± 8.58 | 208.3 ± 10.4 | 466.0 ± 31.2* |
72 | 49.7 ± 1.5 | 23.3 ± 2.1* | >100 | >100 | 29.9 ± 0.6 | 25.9 ± 3.08 | 79.5 ± 0.5 | 419.0 ± 45.6* |
96 | 30.7 ± 2.5 | 22.0 ± 0.3* | 94.3±2.1 | 89.7 ± 0.6 | 19.2 ± 2.2 | 19.1 ± 0.7 | 79.7 ± 1.5 | 402.0 ± 2.1* |
120 | 23.3 ± 0.6 | 12.2 ± 3.1* | 88.6±1.5 | 87.6 ± 4.1 | 27.8 ± 2.4 | 21.7 ± 1.2 | 89.7 ± 3.1 | 397.0 ± 8.1* |