Efficacy of intravenous methylene blue, intravenous artesunate, and their combination in preclinical models of malaria

Table 2 Aotus experiments

Experiment No 1 methylene blue alone
IV MB dose (mg/kg/day × 3 days)	Clearance day*	Recrudescence day*
8	5	7
8	5	7
16	5	7
16	5	9
24	5	7
24	5	8
Experiment No 2 methylene blue plus artesunate
Drug regimen**	Clearance day*	Recrudescence day*
AS8	4	13
AS8	4	9
AS8	5	8
MB8	4	7
MB8	4	7
MB8	6	7
MB8 plus AS8	3	9
MB8 plus AS8	(Not clear)
MB8 plus AS8	7	9

*Day 1 is the first day of treatment. Day 4 is the first day after three days of therapy.
**MB4, MB8, AS4, and AS8 signify IV MB 4 mg/kg/day × three days, MB 8 mg/kg/day × three days, IV AS 4 mg/kg/day × three days, and AS 8 mg/kg/day × three days, respectively.
Each row represents data from one animal.

ISSN: 1475-2875