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Table 1 Cumulative statistics of TK900D calibration standards and quality control samples

From: The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice

Parameters Calibration standards and nominal concentrations (ng/ml)
  STD B STD C STD D STD E STD F STD G STD H STD I STD J
  3.910 7.821 15.64 31.28 62.57 125.0 250.0 500.2 1000
Mean 4.051 7.524 15.48 30.94 64.10 126.6 251.7 496.6 996.3
% Nom 103.6 96.2 99.0 98.9 102.5 101.3 100.7 99.3 99.6
% CV 3.4 4.3 1.7 3.9 2.2 1.9 0.6 0.9 0.9
% Bias 3.6 -3.8 -1.0 -1.1 2.5 1.3 0.7 -0.7 -0.4
N 6 6 6 6 6 6 6 6 6
Parameters Quality control samples and nominal concentration (ng/ml)
  QC A QC B QC C QC D QC E QC F QC G QC H DIL
  3.909 10.01 20.01 60.03 160.1 400.2 800.0 1600
  LLOQ Low ---- ---- Medium ---- High Dilution
Mean 3.815 10.12 21.13 63.42 177.5 436.2 840.9 1673
% Nom 97.6 101.1 105.6 105.7 110.9 109.0 105.1 104.6
% CV 10.8 5.3 4.5 5.4 5.7 7.1 8.3 5.1
% Bias -2.4 1.1 5.6 5.7 10.9 9.0 5.1 4.6
N 18 18 18 18 18 18 18 6
  1. QCH DIL was used to establish the dilution linearity of the method.