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Table 5 Pharmacokinetic parameters for TK900D and TK900E in male C57/BL6 mice

From: The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice

Parameters TK900D TK900E
Orala IVa Orala IVa
Nominal dose (mg/kg) 40 20 5.0 2.5 40 20 5.0 2.5
Apparent t 1/2 (h) 3.9 6.0 2.3 1.9 4.0 3.6 2.5 1.6
Blood CL total (ml/min/kg) b b 44.8 48.9 b b 51.0 51.2
Vd (l/kg) b b 8.9 7.9 b b 10.3 7.0
Vss (l/kg) b b 9.1 8.7 b b 12.6 6.5
C max (μM) 0.79 0.54 b b 2.81 0.94 b b
T max (h) 1.4 1.4 b b 1.0 0.8 b b
AUC 0 - ∞ (min. μmol/l) 287 256 222 104 541 222 221 107
Bioavailability (%) 16.2 30.8 b b 30.6 25.9 b b
  1. aValues are the mean of 5 animals, bEmpty cells indicate that the value was measured or was not relevant.