Table 5 Allele and genotype frequencies of CYP3A4*1B and CYP3A5*3 in Igombe, Tanzania, and expected frequencies according to Hardy Weinberg equilibrium
Gene | SNP | Allele frequency | Genotype frequency | |||
|---|---|---|---|---|---|---|
wt/wt | wt/mut | mut/mut | Gene allele | |||
CYP3A4 | A392G | G, 78% | 5.4% (5/92) | 32.6% (30/92) | 62% (57/92) | CYP3A4*1B wild type |
A, 22% | ||||||
Expected | 4 | 31 | 56 | |||
CYP3A5 | A6986G | G, 16% | 70.1 (68/97) | 27.9% (27/97) | 2% (2/97) | CYP3A5*3 wild type |
A, 84% | ||||||
Expected | 68 | 26 | 2 | |||
CYP2C8 | G416A | A, 10% | 80% (80/100) | 20% (20/100) | 0% (0/100) | CYP2C8*3 wild type |
G, 90% | ||||||
Expected | 81 | 18 | 1 | |||
CYP2C8 | A805T | T, 19% | 66.1 (158/239) | 29.3% (70/239) | 4.6% (11/239) | CYP2C8*2 wild type |
A, 81% | ||||||
Expected | 159 | 74 | 9 | |||
CYP2B6 | G15631T | T, 36% | 39% (37/95) | 49.4% (47/95) | 11.6% (11/95) | CYP2B6*6 wild type |
G, 64% | ||||||
Expected | 39 | 44 | 12 | |||