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Table 1 Effects of OML-PbMSP1 immunization against P. berghei merozoite challenge

From: Plasmodium berghei circumsporozoite protein encapsulated in oligomannose-coated liposomes confers protection against sporozoite infection in mice

Immunization Antibody titration* Infected/total [lst+2ndtrials] Survival* Protection
  IgGl IgG2a (Number) (Day) (%)
OML-PbMSP1 11636 ± 5593†† 2182 ± 1604†† 11/11 [(5/5) + (6/6)] 19.1 ± 10.9 0
PbMSP1 1333 ± 413 283 ± 132 6/6 14.3 ± 6.7 0
OML-PBS 0 0 11/11 [(5/5) + (6/6)] 11.3 ± 5.3 0
None 0 0 11/11 [(5/5) + (6/6)] 11.8 ± 5.2 0
  1. *Antigen-specific 1gG1 and IgG2a detected by ELISA with recombinant PbMSP1 at 14 days after the last boost. Each value represents the mean titer of antibody ± SD per mouse group.
  2. *Each value represents the average survival day ± SD per mouse group.
  3. Mice were scored as protected when parasitemia was not observed over a 30-day period.
  4. ††Indicates statistically significant differences between the antibody titers of OML-PbMSP1-immunized mice and those of the corresponding mice immunized with naked antigen.
  5. Results represent pooled data of two independent experiments.