Predicted model of the P. falciparum K13 propeller protein. a) Location of the mutation sites relative to the overall model of the protein. The beta-propeller domain of the btb-kelch protein Krp1 (PDB ID: 2WOZ) was used as the modeling template. b) Superimposition of the homology models of the wild type and mutated proteins. Areas where the individual colors of the mutants are illustrated display regions where the mutation affects the predicted fold. These areas are indicated by the black block arrows.