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Table 1 EC/IC 50 of chemistries for AgOAR45A and AgOAR45B

From: Characterization of the Anopheles gambiae octopamine receptor and discovery of potential agonists and antagonists using a combined computational-experimental approach

Receptor

AgOAR45A

AgOAR45B

Agonist

EC 50 (nM)

Octopamine

53

17

Clonidine

2

0.24

Naphazoline

2.2

0.23

Tolazoline

280

5

Tyramine

4600

840

Phentolamine

10

5.8

Serotonin

>50,000 (inactive)

>50,000 (inactive)

Dopamine

>50,000 (inactive)

>50,000 (inactive)

Antagonist

IC 50 (μM)

Chlorpromazine

2.6

9.9

Cyproheptadine

2.8

14

Metaclopramide

9.8

>50 (inactive)

Promethazine

.16

2.0

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Malaria Journal

ISSN: 1475-2875

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