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Table 5 Biological parameters evolution between day 0 and day 3

From: Open-label, randomized, non-inferiority clinical trial of artesunate-amodiaquine versus artemether-lumefantrine fixed-dose combinations in children and adults with uncomplicated falciparum malaria in Côte d'Ivoire

 

AS + AQ

AL

Parameters

D0

D3

P value

D0

D3

p value

Mean Hb level (g/dL) (±SD)

10.53 (±1.98)

9.39 (±2.74)

<10-4

10.57 (±1.84)

8.72 (±2.88)

<10-4

Anaemia (Hb level <11 g/dL) (%)

58.6

70.9

0.014

57.4

79.5

<10-4

Patient with abnormal ALAT (<40UI/L) (%)

79.79

90.40

0.012

75.90

81.89

0.20

Patient with abnormal ASAT (<40UI/L) (%)

55.32

84.07

<10-4

51.79

79.47

<10-4

Mean bilirubin level (±SD)

06.45 (±6.65)

08.26 (±8.30)

0.14

5.50 (±4.81)

8.89 (±9.93)

0.01

Mean creatinine level (±SD)

9.50 (±5.75)

16.03 (±17.64)

<10-4

8.70 (±2.51)

13.68 (±10.86)

<10-4

  1. Abbreviations: AS-AQ, artesunate-amodiaquine; AL, artemether-lumefantrine; D, day; Hb, hemoglobin; ASAT, aspartate amino transferase; ALA, alanine amino transferase.