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Table 3 Markers of chloroquine resistance in isolates obtained during the clinical trial

From: Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi-country randomised clinical trials in African adults

Number of subjects

 

Pfcrt

Resistance mutations, %

 

Tested

K

T

KT

No band

2004-2006a

2006-2007b

Ghana

       

 Study 1134

27

11

16

0

0

59.3

 

 Study 1155

83

52

25

3

3

 

33.7

Uganda

       

 Study 1134

51

1

49

0

1

96.1

 

 Study 1155

       

Zambia

       

 Study 1134

116

85

26

5

0

26.7

 

 Study 1155

77

61

13

3

0

 

20.8

Mali

       

 Study 1134

27

8

18

0

1

66.7

 

 Study 1155

29

5

20

4

0

 

82.8

Burkina Faso

       

 Study 1134

       

 Study 1155

27

19

7

0

1

 

25.9

Kenya

       

 Study 1134

15

2

10

0

3

66.7

 

 Study 1155

7

1

5

0

1

 

71.4

Senegal

       

 Study 1134

       

 Study 1155

6

3

2

1

0

 

50.0

  1. aStudy 1134.
  2. bStudy 1155.
  3. K, wild type; KT, mixed; pfcrt, Plasmodium falciparum chloroquine resistance transporter gene; T, resistant.
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Malaria Journal

ISSN: 1475-2875

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