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Table 3 Management and clinical outcomes of children in the intervention and routine care groups

From: The outcome of a test-treat package versus routine outpatient care for Ghanaian children with fever: a pragmatic randomized control trial

  Study group
  All patients (N = 240) Intervention (N = 121) Routine care (N = 119) P-value
Initial diagnosis     
 Malaria 100 (41.7%) 45 (37.2%) 55 (46.2%) 0.190
 Malaria plus bacterial infection 81 (33.7%) 17 (14.0%) 64 (53.8%) <0.001
 Viral infection 40 (16.7%) 40 (33.1%) 0 (0%) <0.001
 Bacterial infection 19 (7.9%) 19 (15.7%) 0 (0%) <0.001
Treatment at initial diagnosis     
 Artesunate-Amodiaquine only 106 (44.2%) 45 (37.2%) 61 (51.3%) 0.028
 Artesunate-Amodiaquine and Antibiotic 75 (31.2%) 17 (14.0%) 58 (48.7%) <0.001
 Paracetamol only 40 (16.7%) 40 (33.1%) 0 (0.0%) <0.001
 Antibiotic only 19 (7.9%) 19 (15.7%) 0 (0.0%) <0.001
Action taken at day 2 review     
 Treatment completed 2 (0.8%) 1 (0.8%) 1 (0.8%) 1.000
 Continue medication 192 (80.0%) 117 (96.7%) 75 (63.0%) <0.001
 Admit for treatment 9 (3.7%) 0 (0.0%) 9 (7.6%) 0.002
 Change medication 15 (6.2%) 1 (0.8%) 14 (11.8%) <0.001
 Add medication 22 (9.2%) 2 (1.6%) 20 (16.8%) <0.001
Action taken at day 7 review     
 Treatment completed 223 (93%) 120 (99.2%) 103 (87.3%) <0.001
 Continue medication 5 (2.1%) 1 (0.8%) 4 (3.4%) 0.211
 Admit for treatment 1 (0.4%) 0 (0.0%) 1 (0.8%) 0.496
 Change medication 5 (2.1%) 0 (0.0%) 5 (4.2%) 0.029
 Add medication 5 (2.1%) 0 (0.0%) 5 (4.2%) 0.029
Clinical outcome at end of study     
 Completed treatment and well 216 (90.0%) 120 (99.2%) 96 (80.7%) <0.001
 Admitted to hospital 10 (4.2%) 0 (0.0%) 10 (8.4%) 0.001
 Remained febrile 13 (5.4%) 1 (0.8%) 12 (10.1%) 0.001
 Death 1 (0.4%) 0 (0.0%) 1 (0.8%) 0.496