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Figure 1 | Malaria Journal

Figure 1

From: Diversity-oriented synthesis and activity evaluation of substituted bicyclic lactams as anti-malarial against Plasmodium falciparum

Figure 1

Overview of the synthesis of substituted chiral bicyclic lactams as potential anti-malarials. (A) The scheme depicts the synthesis of chiral bicyclic lactams from phenylalaninol/levulinic acid and 3-(2- nitrophenyl)levulinic acid. The final compounds were derived either via enolization and alkylation with o-nitrobenzylbromide and subsequent hydrogenation or by lewis acid based ring opening and subsequent cyclization. (B) Screening of synthesized compounds for P. falciparum growth-inhibitory activities at four different concentrations of 1 μM, 10 μM, 25 μM, and 50 μM. Bar graph indicates compounds C and D as the most potent inhibitor of P. falciparum growth. Three independent assays were performed in duplicates. The error bars show the standard errors of the means.

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