Figure 2

Effect of compounds C and D on parasite growth. (A) Percent parasite growth curve showing the effect of compounds C and D on P. falciparum growth at different concentrations of 0.5 μM, 1 μM, 5 μM, 10 μM, 20 μM, 25 μM, and 50 μM. Three independent experiments were performed in duplicates. (B) Comparison of parasite intra-erythrocytic maturation in presence and absence of compounds C and D. Light microscopy Giemsa-stained images of P. falciparum- infected RBCs at 12, 26, 48, and 54 hpi incubated with and without compounds. Bars indicate relative percent frequency of parasite ring, trophozoite and schizont stages in the 12, 26, 48, and 54 hpi. Healthy trophozoites are observed 26 hpi, either in presence or absence of compounds. At 48 hpi, healthy new rings are observed in untreated control but, are >70% reduced in the presence of 50 μM of compound C and compound D with parasite growth arrested as early and late trophozoites.