Figure 3
Growth-inhibitory activities of compounds across different Plasmodium falciparum strains and on viability of COS-7 cells. (A) Bar graph showing the growth-inhibitory effect of dintro-substituted compound C at 50 μM concentration on sorbitol synchronized P. falciparum drug-sensitive clones 3D7, HB3 and drug-resistant clones Dd2. (B) Bar graph showing the growth inhibitory effect of diamine-substituted compound D at 50 μM concentration on sorbitol synchronized P. falciparum drug-sensitive clones 3D7, HB3 and drug-resistant clones Dd2. Three independent assays were performed in duplicates. The error bars show the standard errors of the means. (C) Bar graph showing percentage survival of COS-7 cells after 24 hours of treatment with compounds C and D. Three independent assays were performed in duplicates. The error bars show the standard errors of the means.