Figure 3

Metabolites associated with different developmental stages of Plasmodium falciparum within in vitro gametocyte cultures. (A) Medium metabolite levels for P. falciparum (Pf) cultures and uninfected erythrocyte cultures sampled during culture progression. Red indicates metabolite consumed from medium, green indicates released into medium. For comparison, culture parasite stage composition for the different time points is indicated in blue; GCT, gametocytes. (B) Culture metabolite trajectories for glucose and reported Plasmodium glycolytic endpoints. (C) Culture metabolite trajectories for selected lipid moieties. Graphs show means ± SEM as error bars. *P < 0.05; **P < 0.01; ***P < 0.001 Mann-Whitney U test.