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Table 1 Metabolites significantly altered by Plasmodium falciparum infection throughout gametocyte culture period

From: Changes in metabolic phenotypes of Plasmodium falciparum in vitro cultures during gametocyte development

  Metabolite p-values
   Day 1 Day 4 Day 7 Day 8 Day 14
Metabolites released into medium Acetate 0.0046 0.0005 0.0008 0.0024 0.0024
Alanine 0.0012 0.0005 0.0008 NS 0.0188 (-)
Glycerol 0.0012 0.0005 0.0153 NS NS
Histidine 0.0129 0.0005 0.0008 0.0036 NS
Lactate 0.0012 0.0005 0.0008 0.0024 0.0024 (-)
Ornithine 0.0129 NS NS NS NS
Phenylalanine 0.0014 0.0005 0.0008 0.0188 NS
Pyroglutamate NS NS NS 0.0444 (-) 0.0210 (-)
Pyruvate 0.0012 0.0005 0.0008 0.0024 0.0250 (-)
Tyrosine 0.0046 0.0007 0.0090 NS NS
Valine 0.0033 0.0005 0.0153 NS NS
Metabolites consumed from medium Arginine 0.0166 (-) NS NS NS NS
Glucose NS 0.0005 0.0038 0.0091 0.0152
Glutamine 0.0033 (-) NS NS NS NS
Hypoxanthine NS NS 0.0125 (-) NS NS
myo-Inositol NS NS NS NS 0.0210 (-)
Isoleucine NS 0.0012 NS NS 0.0250
Lipid/Sugar CH = CH NS NS NS NS NS
Lipid CH = CH-CH2-CH2 NS NS NS NS 0.0414
Lipid CH2 NS NS NS NS 0.0414
Lipid CH2-CH2-CO 0.0222 (-) NS NS NS NS
Lipid CH2-CO 0.0033 (-) NS NS NS NS
Lipid CH3 0.0397 (-) NS NS NS 0.0180
Variable consumption/release Leucine 0.0065 (-) 0.0005 0.0296 NS 0.0188 (-)
  1. Statistical differences between metabolite levels of medium from parasite cultures and uninfected erythrocytes, assessed for each time-point as measured via Mann-Whitney U-test. P-values indicate significantly higher metabolite release/consumption by parasite cultures, unless marked with (-), where release/consumption was lower than erythrocytes. NS, no significant difference.