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Table 2 Cytotoxicity of CQ and CQAn and SI on P . falciparum parasites and therapeutic activity or selectivity index (SI), a ratio between toxicity and activity

From: Antiplasmodial activity of chloroquine analogs against chloroquine-resistant parasites, docking studies and mechanisms of drug action

Molecule

Cytotoxicity* MLD 50 (μM)

SI(MLD 50 /IC 50 )

HepG2 cells

W2 (CQ-R)

3D7 (CQ-S)

CQAn28

1508.56 ± 344.50

2125

101

CQAn33

152.89 ± 12.86

7645

131

CQAn34

943.29 ± 73.15

4101

3144

CQAn37

1699.24 ± 10.07

24275

2981

CQAn39

≥3207.08

5011

1342

CQAn45

1015.84 ± 42.97

1319

868

Chloroquine

410.4±26.6

1080

5,679

  1. *Average ± SD of two to four experiments measured through MTT-colorimetric assay.