Antiplasmodial activity of chloroquine analogs against chloroquine-resistant parasites, docking studies and mechanisms of drug action

Table 3 Anti-malarial activity of chloroquine (CQ) and its analogs (CQAn) against P . berghei evaluated as percentage reduction of parasitaemia on days after inoculation with either a CQ sensitive or resistant strain of the parasite*

*Reduction calculated in relation to control non-treated mice (100% of parasite growth).
^aAdapted from de Souza et al. [19]; all the compounds were used at 50mg/Kg, except as indicated, in the dose of 25 mg/Kg because there was not enough material for a higher dose^b. In the case of CQ used as control in the test with the resistant parasites, the dose used was 150 mg/Kg, which was totally inactive, as expected^c.

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