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Table 1 Individual IC 50 and IC 90 values for respective immunosuppressive drugs are shown for each tested parasite sample and for chloroquine resistant strains, respectively

From: In vitro activity of immunosuppressive drugs against Plasmodium falciparum

Individual IC50and IC90values1

Median IC50and IC90values

 

3d7

7G8

Dd2

Strain 1

Strain 2

CQr2parasites

 

IC50

IC90

IC50

IC90

IC50

IC90

IC50

IC90

IC50

IC90

IC50

IC90

Mycophenolic acid

5.3

15.1

5.4

15.3

5.7

16.7

5.4

14.4

6.4

23.7

5.6 (5.4-5.9)3

16 (15.1-18.5)

Rapamycin

8.1

12.5

6.7

11.8

6.6

12.3

7.2

12.7

7.8

12.7

6.9 (6.6-7.4)

12.5 (12.2-12.7)

Everolimus

7.5

11.8

5.1

10.7

6.4

11.5

5.8

11.2

6.2

11.6

6 (5.7-6.3)

11.3 (11.1-11.5)

Chloroquine

0.01

0.03

0.19

1.05

0.22

1.09

0.21

0.65

0.27

0.73

0.21 (0.2-0.23)

0.9 (0.7-1.1)

  1. 1 in μmol/L, 2 Chloroquine resistant, 3 interquartile range.