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Figure 2 | Malaria Journal

Figure 2

From: The effect of UGTs polymorphism on the auto-induction phase II metabolism-mediated pharmacokinetics of dihydroartemisinin in healthy Chinese subjects after oral administration of a fixed combination of dihydroartemisinin-piperaquine

Figure 2

Representative full-scan chromatograms of (A) a blank human plasma sample spiked with dihydroartemisinin (DHA; 40 nM), the glucuronide of DHA (DHA-Glu; 40 nM) and IS (QHS, 4 μM); (B) a human (subject H3) plasma sample at 1.5 h after the first oral dose of DHA (80 mg); and (C) a human (subject H3) plasma sample at 1.5 h after the fourth oral dose of DHA (80 mg). I: DHA (m/z 302.1962); II: the glucuronide of DHA (m/z 478.2283); III: IS (m/z 283.1540).

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Malaria Journal

ISSN: 1475-2875

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