Dose–response relationships for single-dose primaquine in reducing the infectivity of Plasmodium falciparum- infected subjects to anopheline mosquitoes. Pooled data from all studies conducted . Vertical axes shows the proportions of fed anopheline mosquitoes which were infected. Upper (a): Oocyst formation assessed from blood sampled 48 hours after primaquine dose; Lower (b): Sporozoite formation assessed from blood sampled 48 hours after primaquine dose. Primaquine given with an artemisinin derivative is shown in green circles, and with no anti-malarial or a non-artemisinin derivative is shown in red circles. In these studies 29 patients received no primaquine. The size of the circle is proportional to the number of subjects in each group (shown within). Corresponding adult primaquine doses are indicated in square boxes.