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Figure 3 | Malaria Journal

Figure 3

From: Lambda-carrageenan treatment exacerbates the severity of cerebral malaria caused by Plasmodium berghei ANKA in BALB/c mice

Figure 3

Brain histopathology. (A) CGN group. No apparent lesions are observed (Haematoxylin-Eosin stain). Bar, 20 μm. (B) PbN group. Microthrombus consisting of fibrin pigmented RBCs and accumulated mononuclear cells, is observed. Perivascular infiltration of inflammatory cells is not observed. Vascular endothelium is not hyperplastic (arrows indicate endothelial cells). Bar, 20 μm. (C) PbCGN group. Microthrombus consisting of fibrin, pigmented RBCs, pigmented macrophages, and mononuclear cells is observed. Perivascular infiltration of inflammatory cells, haemorrhage in perivascular space, and hyperplastic vascular endothelium are also observed. Bar, 20 μm. (D) PbCGN group. Infected RBCs and inflammatory cells can be seen within the blood vessels of the cerebrum. Note the hyperplastic endothelium, characterized by increased number of endothelial cells (arrow). Adhesive Pb-laden macrophages (shown by white arrow) can also be seen. Bar, 20 μm.

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