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Figure 5 | Malaria Journal

Figure 5

From: PfRON3 is an erythrocyte-binding protein and a potential blood-stage vaccine candidate antigen

Figure 5

Immunogenicity of PfRON3 and invasion inhibition of PfRON3-specific antibodies. (A) Immunorecognition of PfRON3 by the sera of individuals living a malaria endemic area was analyzed via ELISA assay. The sera were diluted at 1:100 to 1:800. The results show that PfRON3 is well recognized by the antibodies in the sera, while the negative control sera did not react with the protein. The bars represent the mean and standard error values of the three experiments. (B) The inhibitory effect of PfRON3-specific IgG on merozoite invasion was tested. Anti-PfRON3 and anti-MSP1-42 specific IgG were diluted in concentrations ranging from 10 to 250 μg/ml. IgG from healthy rabbits was used as a negative control. The results show that PfRON3- and MSP-1-specific IgG inhibited parasite proliferation in a dose-dependent manner. Meanwhile, the control rabbit IgG had no inhibitory effect at any concentrations. The bars represent the mean and standard error values of the three experiments.

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