Heterogeneous genetic diversity pattern in Plasmodium vivax genes encoding merozoite surface proteins (MSP) -7E, −7F and -7L

Table 3 Average number of pvmsp-7 gene synonymous substitutions per synonymous site (d _S ) and non-synonymous substitutions per non-synonymous site (d _N )

n	Gene	5′-end		Central		3′-end		Full-length gene
Worldwide isolates		d_S(SE)	d_N(SE)	d_S(SE)	d_N(SE)	d_S(SE)	d_N(SE)	d_S(SE)	d_N(SE)
35	*msp-7E*	0.0488 (0.0118)•	0.0082 (0.0032)	0.0717 (0.0163)	0.1573 (0.0134)•	0.0665 (0.0130)•	0.0171 (0.0045)	0.0626 (0.0078)	0.0551 (0.0055)
41	*msp-7F*	0.0000 (0.0000)	0.0000 (0.0000)	0.0000 (0.0000)	0.0013 (0.0012)	0.0000 (0.0000)	0.0018 (0.0018)	0.0000 (0.0000)	0.0011 (0.0007)^
36	*msp-7L*	0.0006 (0.0005)	0.0000 (0.0000)	0.0000 (0.0000)	0.0012 (0.0008)	0.0013 (0.0012)	0.0008 (0.0008)	0.0006 (0.0005)	0.0007 (0.0004)
Colombian isolates
31	*msp-7E*	0.0473 (0.0115)•	0.0079 (0.0032)	0.0706 (0.0168)	0.1549 (0.0135)•	0.0633 (0.0124)•	0.0161 (0.0042)	0.0606 (0.0077)	0.0539 (0.0056)
36	*msp-7F*	0.0000 (0.0000)	0.0000 (0.0000)	0.0000 (0.0000)	0.0012 (0.0011)	0.0000 (0.0000)	0.0017 (0.0016)	0.0000 (0.0000)	0.0010 (0.0007)^
31	*msp-7L*	0.0000 (0.0000)	0.0000 (0.0000)	0.0000 (0.0000)	0.0012 (0.0009)	0.0010 (0.0010)	0.0009 (0.0008)	0.0004 (0.0004)	0.0007 (0.0004)

SE: standard error. 5′-end (pvmsp-7E: nucleotide 1–390, pvmsp-7F: nucleotide 1–432, pvmsp-7L: nucleotide 1–381), central (pvmsp-7E: nucleotide 391–747, pvmsp-7F: nucleotide 433–1,053, pvmsp-7L: nucleotide 382–816) and 3′-end (pvmsp-7E: nucleotide 748–1,158, pvmsp-7F: nucleotide 1,054–1,449, pvmsp-7L: nucleotide 817–1,275). Numbering based on Additional files4,9 and10. ^: p = 0.06, •: p <0.001.

ISSN: 1475-2875