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Table 1 Patient characteristics

From: Fixed dose artesunate amodiaquine – a phase IIb, randomized comparative trial with non-fixed artesunate amodiaquine

Characteristic

FD ASAQ

NF ASAQ

P value

N = 26

N = 28

Age

23.1 (17.9-60.1)

24.2 (18.1-56.9)

0.98

Gender (n, M/F)

12/14

13/15

0.98

Luo ethnic group [N(%)]

23 (88.5)

24 (85.7)

1.00

Symptoms [N(%)]

 Headache

23 (88.5)

26 (92.9)

0.66

 Anorexia

18 (69.2)

14 (50.0)

0.15

 Nausea

16 (61.5)

17 (60.7)

0.95

 Weakness

13 (50.0)

15 (53.6)

0.79

 Vomiting

12 (46.2)

16 (57.1)

0.42

 Abdominal pain

10 (38.5)

13 (46.4)

0.55

 Diarrhoea

3 (11.5)

6 (21.4)

0.47

 Cough

1 (3.8)

4 (14.3)

0.35

Signs (range)

 Weight (kg)

58.0 (50.0-90.0)

60.0 (39.0-82.0)

0.78

 Temperature (°C)

37.2 (36.0-39.0)

37.2 (35.8-40.0)

0.42

 Pulse rate (beats/min)

92.5 (62.0-124.0)

90.5 (57.0-131.0)

0.90

 Systolic blood pressure (mmHg)

119.5 (90.0-157.0)

125.5 (85.0-160.0)

0.48

 Diastolic blood pressure (mmHg)

70.0 (55.0-92.0)

74.0 (51.0-99.0)

0.37

 Palpable spleen

0

1/27 (3.7)

1.0

 Palpable liver

0

0

-

Laboratory results (range)

 Asexual parasitaemia/µL

18,479 (8,927-33,915)

13,742 (5,069-23,948)

0.56

 Gametocyte carriage (n, %)

1 (3.8)

0 (0.0)

0.48

 Haemoglobin (g/dL)

13.3 (10.3-17.6)

13.2 (9.9-17.7)

0.53

 White blood cells (× 103/µL)

5.6 (5.2-6.8)

5.1 (2.3-9.5)

0.09

 Neutrophils (× 103/µL)

3.5 (1.3-5.6)

2.6 (0.8-8.1)

0.02

 Lymphocytes (× 103/µL)

1.3 (0.5-2.5)

1.3 (0.5-3.3)

0.22

 Monocytes (× 103/µL)

0.8 (0.6-1.1)

0.6 (0.4-0.8)

0.005

 Eosinophils (× 103/µL)

0.07 (0.03-0.58)

0.08 (0.05-0.19)

0.60

 Platelets (× 103/µL)

96.0 (44.0-229.0)

95.5 (18.0-254.0)

0.86

 AST* (IU/L)

28.0 (13.4-82.9)

31.2 (15.1-56.1)

0.99

 ALT* (IU/L)

21.6 (10.5-123.1)

23.2 (3.8-105.9)

0.37

 Total bilirubin (µmol/L)

12.0 (1.7-50.6)

13.1 (0.0-65.3)

0.74

 Creatinine (µmol/L)

70.7 (17.7-113.2)

75.6 (53.0-114.9)

0.26

  1. All continuous data are expressed as median (range).
  2. *AST – aspartate aminotransferase, ALT- alanine aminotransferase.