Publication, country, reference | Description of recipient | Description of donor | Diagnostic test results for donor | Time lapse since donor’s last infection/risk of infection |
---|---|---|---|---|
Black et al., Australia [21] | Adult female with carcinoma; peri-operative blood transfusion in 1958, with fever 7 days post transfusion. Falciparum malaria diagnosed subsequently (confirmed by microscopy 14 days after transfusion) | Merchant seaman with trips to malarious areas 1942–7 and intermittent anti-malarials. History of malaria, most recent in Solomon Islands in 1953. Back in Australia since April 1957. | Slide positive | 15 months |
Chojnacki et al., USA [22] | 60-years-old male with anaemia and myocardial infarction transfused who developed fever and chills 4 days post transfusion with falciparum malaria confirmed subsequently | 19-years-old soldier, served in Vietnam until 7 months before blood donation. Had taken prophylaxis. Recalled short fever episode in Vietnam | >20 slides negative. Sternal bone marrow aspirate + by microscopy | 7 months |
Fisher et al., USA [23] | Case 1: 54-years-old American female transfused during aorto-iliac bypass graft surgery in 1968. Developed fever 13Â days post transfusion with falciparum malaria confirmed by microscopy nine days later. No relevant travel history | 22-years-old American soldier in Vietnam 1966- March 1967. Took prophylaxis. | Positive serology; negative microscopy | 13Â months |
Case 2: 25-years-old female, transfused for post-partum haemorrhage. Developed fever ~2 weeks later and then severe malaria with coma. Diagnosis finally made 3 weeks post transfusion. | 21-years-old American soldier in Viet Nam 1967–1968. Took prophylaxis. | Negative microscopy | 7 months | |
Brooks et al.,USA[24] | 56-years-old male with laryngeal carcinoma. Post-surgical transfusion; no relevant travel history. Died of cerebral malaria about 3Â weeks post operatively. | Nigerian student. | Rare P.F T seen finally after multiple negative smears and a 500Â ml phlebotomy. | 32Â months |
Dike, UK [25] | Adult male, given blood transfusion after a road traffic accident. Developed fever 19Â days later and falciparum malaria confirmed 24Â days after last transfusion | Nigerian student. Asymptomatic | Serology positive. | 17Â months |
Seligman et al., USA [26] | 34-years-old male. End-stage renal failure on haemodialysis, born in Italy, in USA since 1955. Monthly blood transfusions. Developed falciparum malaria in 1970 with symptoms 7Â days post transfusion. No relevant travel history. | Ghanaian, immigrated to USA in Oct 1969. No history of malaria. | One P.F T ring form found on thin smear. Serology positive. | 13Â months |
Duizabo et al., France [27] | No details* | No details | No details | 16Â months |
Besson et al., France [28] | 30-years-old male. Orthopaedic surgical procedure (correction of pseudarthrosis) with transfusion in 1973. Fever 2Â weeks later.Eventual microscopy diagnosis of falciparum malaria. Had never left France and no history of malaria. | Donor born in Senegal, living in France since 1960, no history malaria. | Serology (IF) positive | 13Â years |
Saleun et al., France [29] | No details. P. falciparum transmitted by blood transfusion | Donor from Burkina Faso | No details | 16Â months |
Duperval et al., Canada [30] | 8-years-old Canadian male, treated for chronic lymphocytic leukaemia, admission with high fever. Cerebral malaria diagnosed post-mortem, including sequestration of parasitised erythrocytes in cerebral vasculature. Last recorded blood transfusion was post gastrectomy 12Â years earlier. No travel; route/time of malaria acquisition unknown. 50% parasitaemia on pre-mortem slides examined retrospectively. | No donor history | No details | 12Â years |
Babinet et al., France [31] | 53-years-old Portuguese female with left ventricular insufficiency, admitted for heart transplant. Developed symptoms of malaria 12Â days post op, diagnosed on day 18. She died 4Â days later** | 51-years-old female originally from Cameroon | Donor's serum tested retrospectively was positive for P. falciparum Abs and Ag | 15Â months |
Yarrish et al., USA [32] | 65-years-old female, transfused at cardiothoracic surgery (for rheumatic mitral stenosis) in 1982. Developed post transfusion falciparum malaria with 5% parasitaemia diagnosed by microscopy 16Â days post surgery. No relevant travel history. | Ghanaian male residing in USA for 6Â years. Last trip to Ghana the year prior to donation | Positive P.F serology | 10Â months |
Stickland et al., Australia [33] | 83-years-old female with myelodysplastic syndrome; transfusion dependent. 1991: developed falciparum malaria 23Â days post- transfusion diagnosed by microscopy of blood and bone marrow aspirate. No relevant travel history. | Donor was previously a long-term resident of Papua New Guinea. | No laboratory confirmation | 8Â months |
Slinger et al., Canada [34] | Case 1: 62-years-old female, post transfusion falciparum malaria in 1997. No history of travel to malarious area | Donor 1: 19-years-old female from Ghana originally and living in Canada for 4Â years. | Unable to get a sample for screening | 4Â years |
Case 2: 24-years-old female developed fever 15Â days post transfusion with P. falciparum confirmed 3Â days later | Donor 2: male, originally from Mali. History of malaria treated with chloroquine in 1991 | Donor 2: PCR positive for P.F | 4Â years | |
Case 3: 63-years-old male, P. falciparum malaria 16Â days after platelet transfusion | Donor 3: Originally from Cameroon. | Donor 3: Rare P.f. T and gametocytes slide | 3Â years and history of malaria 13Â years previously | |
Frey-Wettstein et al., Switzerland [35] | 70-years-old male with ischaemic heart disease and aortic aneurysm, transfused peri-operatively in 1999. Developed post-transfusion falciparum malaria with symptoms 2Â weeks post-op (confirmed by microscopy 1Â week later) and died. | 30-years-old male born in Cameroon, with history of malaria aged 15Â years. Moved to Europe 10Â years before blood donation. Last trip to Cameroon 6Â years before. | Serology positive and later slide positive (gametocytes and P.f. T) | 6Â years |
MMWR USA [36] | 69-years-old male, transfused in 2003 following upper gastrointestinal bleed. No relevant travel history. Re-admitted 2–3 weeks post transfusion with falciparum malaria diagnosed by microscopy. | 18-years-old blood donor of Ghanaian origin living in USA for 11 months. Treated for malaria 2 years previously. | Slide and PCR negative. Serology (IFA) positive. | 11 months |
Bruneel et al., France [37] | 81-years-old male, Type 2 diabetes mellitus, post transfusion cerebral malaria and death in 2002. Symptoms developed 2Â weeks post transfusion. No travel to an endemic area for 20Â years. | 19-years-old female, originally from sub-Saharan Africa. Living in France for 4Â years | Positive PCR for P.falciparum and negative thick film' in the 'Diagnostic test results for donor' | 4Â years |
Kitchen, UK [38] | Case 1: 72-years-old female with acute leukaemia, never visited malarious area. Developed falciparum malaria 13Â days after multiple blood product transfusions (probably from platelet transfusion) | Male, UK born, worked in Africa for 10Â years and history of malaria. | Serology (IFAT) positive | 2Â years |
Case 2: Male with diabetes and Non-Hodgkins Lymphoma, presenting with falciparum malaria more than 2Â weeks after a transfusion. Travelled to Kenya the year before | Female, Nigerian but UK resident since childhood. Three trips to Ghana | Serology (EIA and IFAT) positive | 6Â months | |
Case 3: 62-years-old male, fever 4Â days post transfusion for gastrointestinal bleeding in 1997. Served in Egypt in WWII. Otherwise no travel. Died of cerebral malaria. | 19-years-old, Ghanaian female. UK national since aged 6Â months. Travelled to Uganda in 1994 travelled to Uganda for 6Â weeks where she reported undiagnosed fever. | Slide negative. Serology (EIA and IFAT) positive | 3Â years | |
Case 4: 51-years-old male with sickle cell anaemia and chronic renal failure. Post transfusion falciparum malaria in 2003. No history of travel to malarious area. Left Jamaica for UK in 1957. | 38-years-old female, Ghanaian, visited Ghana last in 1996 | Slide positive Serology (EIA and IFAT) positive | 7Â years | |
MMWR USA [39] | 25-years-old female with sickle cell anaemia, multiple transfusions in 2007, admitted with falciparum malaria (16% parasitaemia) more than 1Â month post transfusion. | Donor of Nigerian origin in USA since 2001 with no travel in the intervening period. Hospitalized with fever presumed malaria in 1988 | Serology positive | 6Â years |
MMWR USA [40] | Case 1: 27-years-old male with fever 3Â weeks post blood transfusion. No travel outside Florida | 27-years-old old donor of Nigerian origin in USA since 2004 with no travel in the intervening period. History of malaria 15Â years previously | Serology (IFA) positive, PCR negative | 5Â years |
Case 2: 78-years-old male receiving chemotherapy for lung carcinoma diagnosed with falciparum malaria after anaemia investigated. Several blood transfusions in previous 10 months, most recent 2–4 weeks previously. No travel in the last year. | 30-years-old female, lived in East Africa as a child and travelled to Uganda, China, Brazil 13–17 months before donating | PCR negative, Serology (IFA) positive | 13-17 months | |
MMWR USA [41] | 55-years-old female; cardiac surgery and blood transfusion. Re-admitted 1Â month later with falciparum malaria (microscopy and PCR positive). No recent relevant travel. | 21-years-old male, born in Russia, lived in Benin for 17Â years before immigrating to USA. No travel to endemic area in past 4Â years | Slide and RDT neg, Serology and PCR positive (and PCR matched recipient P.F) | 4Â years |
Lefavour et al., USA [42] | 27-years-old Ghanaian female, living in USA since 1972 with end stage renal failure. Developed post-transplant falciparum malaria 2Â weeks after receiving live related transplant from her mother. Treated, rejected kidney, graft nephrectomy. Second transplant a year later (cadaveric). Post transplant falciparum malaria 5Â months later. | Donor 1 (mother)- from Ghana | Donor 1 (mother): serology positive | 23Â months |
 |  | Donor 2: no information | Donor 2: serology negative |  |