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Figure 4 | Malaria Journal

Figure 4

From: Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains

Figure 4

Association of antibody response against 3D7-D 20 mers and protection from malaria in children. Sera from children 1–5 years old (N = 186) living in Tanzania were used at dilution 1/200 to perform ELISA on 3D7-D LSP and its corresponding 20 mers. A) Log rank chi-squares statistics from Kaplan-Meier analysis testing the association of malaria morbidity rates with adjusted Ab OD for age. The p values (p) test the hypothesis that the 3D7-D and each 20-mer specific antibodies are associated with clinical protection. Since peptides P11, P12 and P13 showed the highest likelihood association values with protection, P2604 containing those three 20 mers sequences was synthesized and tested in children 1–5 years old (N = 190) living in Tanzania with its constitutive 20 mers, 3D7-D and 3D7D - + 8aaC. B) Shows profile curve of Ab responses (arithmetic mean OD). C) Shows Log rank Chi-square from Kaplan-Meier analysis determining the relationship between malaria morbidity, Ab OD and age for each peptide.

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