Low genetic diversity and functional constraint in loci encoding Plasmodium vivax P12 and P38 proteins in the Colombian population

Table 3 Synonymous substitution per synonymous site rate (d _S ) and non-synonymous substitution per non-synonymous site rate (d _N ) for pv12 and pv38 genes

n	Gene	Region A		Region B		Full length gene
		d_S(se)	d_N(se)	d_S(se)	d_N(se)	d_S(se)	d_N(se)
Worldwide isolates
76	*pv12*	0.000 (0.000)	0.001 (0.001)	0.000 (0.000)	0.000 (0.000)	0.000 (0.000)	0.001 (0.000)
53	*pv38*	0.001 (0.001)	0.003 (0.002)	0.006 (0.004)	0.001 (0.001)	0.004 (0.002)	0.002 (0.001)
Colombian population
70	*pv12*	0.000 (0.000)	0.001 (0.001)	0.000 (0.000)	0.000 (0.000)	0.000 (0.000)	0.000 (0.000)
46	*pv38*	0.001 (0.001)	0.003 (0.002)	0.005 (0.004)	0.001 (0.001)	0.004 (0.002)	0.002 (0.001)

d_N and d_S rates were estimated by using sequences obtained from databases together with Colombian ones (worldwide isolates) and just with those obtained in the Colombian population. n: number of isolates. pv12: region A, nucleotides 1-546 and region B, nucleotides 547-1,095. pv38: region A, nucleotides 1-459 and region B, nucleotides 460-1,065. se: standard error. No statistically significant differences were found.

ISSN: 1475-2875