|
P. vivax/P. Cynomolgi
|
|---|
|
n
|
Gene
|
s48/45 domain in region A
|
s48/45 domain in region B
|
Full-length gene
|
|---|
| |
KS(se)
|
KN(se)
|
KS(se)
|
KN(se)
|
KS(se)
|
KN(se)
|
|---|
|
Worldwide isolates
| | | | | | |
|
78
|
pv12
|
0.016 (0.003)†
|
0.005 (0.002)
|
0.019 (0.004)†
|
0.003 (0.001)
|
0.016 (0.002)*
|
0.004 (0.001)
|
|
54
|
pv38
|
-
|
0.030 (0.007)†
|
0.005 (0.001)
|
0.031 (0.004)*
|
0.007 (0.001)
|
|
Colombian isolates
| | | | | | |
|
71
|
pv12
|
0.018 (0.003)†
|
0.005 (0.001)
|
0.021 (0.004)†
|
0.003 (0.001)
|
0.016 (0.002)*
|
0.005 (0.001)
|
|
47
|
pv38
|
-
|
0.033 (0.007)†
|
0.006 (0.001)
|
0.033 (0.004)*
|
0.008 (0.001)
|
|
P. vivax/P. knowlesi
|
|
n
|
Gene
|
s48/45 domain in region A
|
s48/45 domain in region B
|
Full-length gene
|
| |
K
S
(se)
|
K
N
(se)
|
K
S
(se)
|
K
N
(se)
|
K
S
(se)
|
K
N
(se)
|
|
Worldwide isolates
| | | | | | |
|
78
|
pv12
|
0.025 (0.005)†
|
0.006 (0.002)
|
0.020 (0.004)†
|
0.003 (0.001)
|
0.022 (0.003)*
|
0.005 (0.001)
|
|
54
|
pv38
|
-
|
0.028 (0.006)†
|
0.005 (0.001)
|
0.034 (0.004)*
|
0.007 (0.001)
|
|
Colombian isolates
| | | | | | |
|
71
|
pv12
|
0.027 (0.006)†
|
0.006 (0.001)
|
0.022 (0.005)†
|
0.003 (0.001)
|
0.023 (0.002)*
|
0.005 (0.001)
|
|
47
|
pv38
|
-
|
0.031 (0.007)†
|
0.005 (0.001)
|
0.038 (0.005)*
|
0.008 (0.001)
|
- KN and KS rates were estimated by using sequences obtained from databases (worldwide isolates) together with Colombian ones, and just with those obtained in the Colombian population. n: number of isolates. pv12 s48/45 domain in region A: nucleotides 82-471; pv12 s48/45 domain in region B: nucleotides 589-906; pv38 s48/45 domain in region B: nucleotides 481-852; -: There are no s48/45 domains in pv38 region A. Numbering is based on the Sal-I reference sequence. *: p < 0.000, †: p < 0.002.
