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Table 4 Synonymous divergence substitution per synonymous site (K S ) rate and non-synonymous divergence substitution per non-synonymous site (K N ) rate

From: Low genetic diversity and functional constraint in loci encoding Plasmodium vivax P12 and P38 proteins in the Colombian population

P. vivax/P. Cynomolgi
n Gene s48/45 domain in region A s48/45 domain in region B Full-length gene
  KS(se) KN(se) KS(se) KN(se) KS(se) KN(se)
Worldwide isolates       
78 pv12 0.016 (0.003)† 0.005 (0.002) 0.019 (0.004)† 0.003 (0.001) 0.016 (0.002)* 0.004 (0.001)
54 pv38 - 0.030 (0.007)† 0.005 (0.001) 0.031 (0.004)* 0.007 (0.001)
Colombian isolates       
71 pv12 0.018 (0.003)† 0.005 (0.001) 0.021 (0.004)† 0.003 (0.001) 0.016 (0.002)* 0.005 (0.001)
47 pv38 - 0.033 (0.007)† 0.006 (0.001) 0.033 (0.004)* 0.008 (0.001)
P. vivax/P. knowlesi
n Gene s48/45 domain in region A s48/45 domain in region B Full-length gene
  K S (se) K N (se) K S (se) K N (se) K S (se) K N (se)
Worldwide isolates       
78 pv12 0.025 (0.005)† 0.006 (0.002) 0.020 (0.004)† 0.003 (0.001) 0.022 (0.003)* 0.005 (0.001)
54 pv38 - 0.028 (0.006)† 0.005 (0.001) 0.034 (0.004)* 0.007 (0.001)
Colombian isolates       
71 pv12 0.027 (0.006)† 0.006 (0.001) 0.022 (0.005)† 0.003 (0.001) 0.023 (0.002)* 0.005 (0.001)
47 pv38 - 0.031 (0.007)† 0.005 (0.001) 0.038 (0.005)* 0.008 (0.001)
  1. KN and KS rates were estimated by using sequences obtained from databases (worldwide isolates) together with Colombian ones, and just with those obtained in the Colombian population. n: number of isolates. pv12 s48/45 domain in region A: nucleotides 82-471; pv12 s48/45 domain in region B: nucleotides 589-906; pv38 s48/45 domain in region B: nucleotides 481-852; -: There are no s48/45 domains in pv38 region A. Numbering is based on the Sal-I reference sequence. *: p < 0.000, †: p < 0.002.