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Table 4 Synonymous divergence substitution per synonymous site (K S ) rate and non-synonymous divergence substitution per non-synonymous site (K N ) rate

From: Low genetic diversity and functional constraint in loci encoding Plasmodium vivax P12 and P38 proteins in the Colombian population

P. vivax/P. Cynomolgi

n

Gene

s48/45 domain in region A

s48/45 domain in region B

Full-length gene

 

KS(se)

KN(se)

KS(se)

KN(se)

KS(se)

KN(se)

Worldwide isolates

      

78

pv12

0.016 (0.003)†

0.005 (0.002)

0.019 (0.004)†

0.003 (0.001)

0.016 (0.002)*

0.004 (0.001)

54

pv38

-

0.030 (0.007)†

0.005 (0.001)

0.031 (0.004)*

0.007 (0.001)

Colombian isolates

      

71

pv12

0.018 (0.003)†

0.005 (0.001)

0.021 (0.004)†

0.003 (0.001)

0.016 (0.002)*

0.005 (0.001)

47

pv38

-

0.033 (0.007)†

0.006 (0.001)

0.033 (0.004)*

0.008 (0.001)

P. vivax/P. knowlesi

n

Gene

s48/45 domain in region A

s48/45 domain in region B

Full-length gene

 

K S (se)

K N (se)

K S (se)

K N (se)

K S (se)

K N (se)

Worldwide isolates

      

78

pv12

0.025 (0.005)†

0.006 (0.002)

0.020 (0.004)†

0.003 (0.001)

0.022 (0.003)*

0.005 (0.001)

54

pv38

-

0.028 (0.006)†

0.005 (0.001)

0.034 (0.004)*

0.007 (0.001)

Colombian isolates

      

71

pv12

0.027 (0.006)†

0.006 (0.001)

0.022 (0.005)†

0.003 (0.001)

0.023 (0.002)*

0.005 (0.001)

47

pv38

-

0.031 (0.007)†

0.005 (0.001)

0.038 (0.005)*

0.008 (0.001)

  1. KN and KS rates were estimated by using sequences obtained from databases (worldwide isolates) together with Colombian ones, and just with those obtained in the Colombian population. n: number of isolates. pv12 s48/45 domain in region A: nucleotides 82-471; pv12 s48/45 domain in region B: nucleotides 589-906; pv38 s48/45 domain in region B: nucleotides 481-852; -: There are no s48/45 domains in pv38 region A. Numbering is based on the Sal-I reference sequence. *: p < 0.000, †: p < 0.002.
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Malaria Journal

ISSN: 1475-2875

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