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Table 1 Base-case values and ranges used in sensitivity analysis

From: Cost-effectiveness analysis of vaccinating children in Malawi with RTS,S vaccines in comparison with long-lasting insecticide-treated nets

Description Value Reference
  Base-case estimate Range for sensitivity analysis (reference for range)
   Low High  
Costs (2012 USD)
Disease costs
Medical costs     
Mild malaria     
Public health systems 0.51 0.26 0.77 [27] (±50%)
Households 0.50 0.21 1.00 [28] (±50%)
Severe malaria (CM, SMA)     
Public health systems 12.76 6.38 19.14 [27] (±50%)
Households 0.50 0.21 1.00 [28] (±50%)
Non-medical costs     
(Productivity costs)
Mild, CM, SMA     
Adults 2.52 1.26 3.78 [16, 27] (±50%)
Children 1.11 0.56 1.67 [16, 27] (±50%)
Death 4.76 2.38 7.14 [16] (±50%)
Vaccine costs
Price per dose 7 1 15 [29, 30] (Min, Max)
Administration per dose 0.37 0.19 0.57 [30] (±50%)
Total costs for 3 doses 22.11 3.57 46.71  
LLINs costs
LLIN per two persons 3.16 2.23 5.23 [31, 32] (Min, Max)
DALY-related parameters
Life expectancy 47.1 years    [23]
Disability weights     [33]
Mild malaria 0.191 0.172 0.211  
CM 0.471 0.443 0.471  
SMA 0.471 0.191 0.471  
Death 1    
Effectiveness parameters
Vaccine protection efficacy
Mild Malaria 0.539 0.496 0.578 [12] (95% CI)
Severe Malaria (CM, SMA) 0.313 0.142 0.448 [12] (95% CI)
Death 0.2 0.15 0.25 [19] (±25%)
Duration of protection 45 months 11 months 10 years [14]
Vaccine coverage 0.85 0.64 0.99 [34, 35] (Min, Max)
LLIN protection efficacy
Mild Malaria 0.5 0.43 0.62 [36] (Min, Max)
Severe Malaria (CM, SMA) 0.45 0.2 0.63 [36] (95% CI)
Death 0.17 0.1 0.24 [36] (95% CI)
Duration of protection 3 years 3 years 5 years [37] (Min, Max)
LLIN coverage 80% 55.4% 80% [7] (Baseline (2010) - Target (2015))
LLIN use 88% 87% 90% [38] (95% CI)
Discount rate% 3% 0% 6% [39]