Cost-effectiveness analysis of vaccinating children in Malawi with RTS,S vaccines in comparison with long-lasting insecticide-treated nets

Malaria Journal

Table 1 Base-case values and ranges used in sensitivity analysis

Description	Value			Reference
	Base-case estimate	Range for sensitivity analysis		(reference for range)
		Low	High
Costs (2012 USD)
Disease costs
Medical costs
Mild malaria
Public health systems	0.51	0.26	0.77	[27] (±50%)
Households	0.50	0.21	1.00	[28] (±50%)
Severe malaria (CM, SMA)
Public health systems	12.76	6.38	19.14	[27] (±50%)
Households	0.50	0.21	1.00	[28] (±50%)
Non-medical costs
(Productivity costs)
Mild, CM, SMA
Adults	2.52	1.26	3.78	[16, 27] (±50%)
Children	1.11	0.56	1.67	[16, 27] (±50%)
Death	4.76	2.38	7.14	[16] (±50%)
Vaccine costs
Price per dose	7	1	15	[29, 30] (Min, Max)
Administration per dose	0.37	0.19	0.57	[30] (±50%)
Total costs for 3 doses	22.11	3.57	46.71
LLINs costs
LLIN per two persons	3.16	2.23	5.23	[31, 32] (Min, Max)
DALY-related parameters
Life expectancy	47.1 years			[23]
Disability weights				[33]
Mild malaria	0.191	0.172	0.211
CM	0.471	0.443	0.471
SMA	0.471	0.191	0.471
Death	1
Effectiveness parameters
Vaccine protection efficacy
Mild Malaria	0.539	0.496	0.578	[12] (95% CI)
Severe Malaria (CM, SMA)	0.313	0.142	0.448	[12] (95% CI)
Death	0.2	0.15	0.25	[19] (±25%)
Duration of protection	45 months	11 months	10 years	[14]
Vaccine coverage	0.85	0.64	0.99	[34, 35] (Min, Max)
LLIN protection efficacy
Mild Malaria	0.5	0.43	0.62	[36] (Min, Max)
Severe Malaria (CM, SMA)	0.45	0.2	0.63	[36] (95% CI)
Death	0.17	0.1	0.24	[36] (95% CI)
Duration of protection	3 years	3 years	5 years	[37] (Min, Max)
LLIN coverage	80%	55.4%	80%	[7] (Baseline (2010) - Target (2015))
LLIN use	88%	87%	90%	[38] (95% CI)
Discount rate%	3%	0%	6%	[39]