Treatment effectiveness pathway. This figure depicts each step along the pathway to malaria treatment effectiveness. At the top of the pathway are the health system factors such as choosing efficacious treatments such as ACT, improving access to those treatments and targeting treatments to those that need it most. The second half of the pathway depicts individual factors that can enhance or disrupt the effectiveness pathway such as provider compliance to treatment guidelines and patient/caregiver adherence to treatment regimens. Source: Original figure courtesy of Marcel Tanner, personal communication 2012 and manuscript published by, The malERA Consultative Group on Health Systems and Operational Research, A Research Agenda for Malaria Eradication: Health Systems and Operational Research. PLoS Med, 2011. 8(1): p. E1000397.