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Table 4 Anti-malarial activity in vitro in 15 different human P . vivax isolates for chloroquine (CQ), artesunate (ART) and mefloquine MQ)

From: Plasmodium vivax and Plasmodium falciparum ex vivo susceptibility to anti-malarials and gene characterization in Rondônia, West Amazon, Brazil

P. vivax isolates % of trophozoites Drugs/IC50Nm
   CQ ART MQ
P006 22 29 15 11
P010 20 61** 11 45
P015 9 13.5 11 6
P022 15 8 11 60
P024 32* 69** 34 113
P025 93* 3.0 28 11
P026 29 51** 137 42
P028 11 6.6 2.8 11
P029 16 34 2.5 5.5
P031 10 15 8.0 8.2
P033 8 23 23 24
P034 17 29 9.6 47
P038 42* 8.5 1.3 2
P037 32* 6.5 9.4 39
P039 88* 6.8 5.2 26
P042 80* 62** 23 15
Mean (±SD) - 23 + 9 32 + 37 32 + 28
  1. *Isolates that presented more than 30% trophozoites. **Isolates that were considered less sensitive to CQ.