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Table 4 Anti-malarial activity in vitro in 15 different human P . vivax isolates for chloroquine (CQ), artesunate (ART) and mefloquine MQ)

From: Plasmodium vivax and Plasmodium falciparum ex vivo susceptibility to anti-malarials and gene characterization in Rondônia, West Amazon, Brazil

P. vivax isolates

% of trophozoites

Drugs/IC50Nm

  

CQ

ART

MQ

P006

22

29

15

11

P010

20

61**

11

45

P015

9

13.5

11

6

P022

15

8

11

60

P024

32*

69**

34

113

P025

93*

3.0

28

11

P026

29

51**

137

42

P028

11

6.6

2.8

11

P029

16

34

2.5

5.5

P031

10

15

8.0

8.2

P033

8

23

23

24

P034

17

29

9.6

47

P038

42*

8.5

1.3

2

P037

32*

6.5

9.4

39

P039

88*

6.8

5.2

26

P042

80*

62**

23

15

Mean (±SD)

-

23 + 9

32 + 37

32 + 28

  1. *Isolates that presented more than 30% trophozoites. **Isolates that were considered less sensitive to CQ.
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Malaria Journal

ISSN: 1475-2875

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