Table 5 Prevalence of molecular markers associated with P . falciparum resistance to chloroquine
Gene – codon | % of mutations | Mutations | Protein change |
|---|---|---|---|
PfMDR1 | |||
86 | 0% | - | - |
184 | 100% | TAT > TTT | Tyrosine > Phenylalanine |
1034 | 84% | AGT > TGT | Serine > cysteine |
1042 | 100% | AAT > GAT | Asparagine > Aspartic acid |
1246 | 100% | GAT > TAT | Aspartic acid > Tyrosine |
PfCRT | |||
72 | 100% | AAA > ACA | Lysine > Treonine |
76 | 100% | TGT > TCT | Cysteine > Serine |