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Figure 2 | Malaria Journal

Figure 2

From: Phenotypic characterization of Plasmodium berghei responsive CD8+ T cells after immunization with live sporozoites under chloroquine cover

Figure 2

CD4+ T cells and CD8+ T cells are required for full protection. A) Infection/cure animals were sacrificed two weeks post suspension of CQ treatment. Splenocytes and/or serum from immunized or non-immunized animals were harvested and transferred into naïve C57BL/6 mice. Groups of ten recipient mice received 2 × 107 cells, 100 μL serum or a combination of both. Twenty-four hours later animals were challenged with 1000 Spz and appearance of parasitaemia was monitored for two weeks (representative of two experiments). B) Ten C57BL/6 wild type, or Ic−/−(MHC II KO), or β2 macroglobulin −/− (MHC I KO) were infected/cured under CQ cover as described, group of animals received CQ alone as a control ( results from one experiment). Two weeks post suspension of the CQ treatment animals were challenged with 1,000 Spz and the appearance of parasitaemia monitored for two weeks.

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