Gene expression profiles associated with apoptosis pathways. Representative example of amplification plot (A). Apoptosis-associated gene expression was evaluated in malaria-naive donors (n = 3) and P. vivax-infected donors (n = 8). Genes were grouped according to the pathway they were involved in: extrinsic pathway (B), intrinsic pathway (C) and apoptosis inhibitors (D). Bars represent fold regulation of genes in CD4+ T cells from P. vivax-infected individuals in relation to the control group (malaria-naive donors) with statistically significant results. Statistical analyses were performed using PCR Array Data Analysis Web Portal (SABiosciences). *p < 0.05, **p < 0.01, ***p < 0.0001.