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Figure 6 | Malaria Journal

Figure 6

From: The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro

Figure 6

Effects of mefloquine on the transcription of ER stress response genes. Changes in the mRNA levels of tubulin, GADD153, GRP78 and PERK induced in rat neurons after exposure to mefloquine (5 min treatment followed by 24 h washout) were quantitated using Affymetrix U34 Rat Genome arrays. Mefloquine (80 μM) upregulated the transcription of GADD153, GRP78 and PERK but not tubulin (one way ANOVA, P < 0.05, n = 20), suggesting that the drug induces an ER stress response at this concentration.

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