Table 2 Changes in the transcriptional modulation of ER stress response genes induced by mefloquine in rat neurons.
Protein | Genbank accession | ANOVA P | Fold-change at: | ANOVA P < 0.05 and FC > 1.3 at 80 μM? | ||
|---|---|---|---|---|---|---|
2 μM | 10 μM | 80 μM | ||||
ER chaperones | Â | Â | Â | Â | Â | Â |
GRP78 | S63521 | 0.0186 | 1.0 | 1.0 | 2.6 | YES |
PDI | X02918 | 0.000219 | 1.0 | 1.0 | 1.7 | YES |
GRP94 | S69315 | 0.004307 | 1.1 | 1.0 | 0.8 | NO |
GRP94 | S69316 | 0.000165 | 1.0 | 1.0 | 2.2 | YES |
ERP29 | U63482 | 0.23012 | 0.8 | 0.9 | 1.3 | NO |
Calreticulin | D78308 | 0.0062 | 1.0 | 1.0 | 1.5 | YES |
ER-relevant transcription factors | Â | Â | Â | Â | Â | Â |
GADD153 | U30186 | 0.00207 | 1.0 | 1.0 | 3.0 | YES |
EIF2α kinases |  |  |  |  |  |  |
PEK/PERK | AF096835 | 0.000587 | 0.7 | 0.9 | 4.6 | YES |
Controls | Â | Â | Â | Â | Â | Â |
Tubulin | AB015946 | 0.926 | 1.2 | 1.0 | 1.0 | NO |