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Table 2 Changes in the transcriptional modulation of ER stress response genes induced by mefloquine in rat neurons.

From: The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro

Protein Genbank accession ANOVA P Fold-change at: ANOVA P < 0.05 and FC > 1.3 at 80 μM?
2 μM 10 μM 80 μM
ER chaperones       
GRP78 S63521 0.0186 1.0 1.0 2.6 YES
PDI X02918 0.000219 1.0 1.0 1.7 YES
GRP94 S69315 0.004307 1.1 1.0 0.8 NO
GRP94 S69316 0.000165 1.0 1.0 2.2 YES
ERP29 U63482 0.23012 0.8 0.9 1.3 NO
Calreticulin D78308 0.0062 1.0 1.0 1.5 YES
ER-relevant transcription factors       
GADD153 U30186 0.00207 1.0 1.0 3.0 YES
EIF2α kinases       
PEK/PERK AF096835 0.000587 0.7 0.9 4.6 YES
Controls       
Tubulin AB015946 0.926 1.2 1.0 1.0 NO