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Table 2 Determination of physicochemical characteristics of mutable residues, and their mean values for protein PfCRT in a transfected clone of P. falciparum.

From: Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine

PFCRT : clone GC03

  

EIS

SCV

CH

 

residue

amino acid

    

72

C

0.04

219.43

0

 

73

M

0.26

327.41

0

 

75

N

-0.64

256.12

0

 

76

K

-1.1

366.25

1

 
 

SUM

-1.44

1169.21

1

 
 

MEAN

-0.275

292.303

0.25

 

72

C

0.04

219.43

0

 

74

M

0.26

327.41

0

 

75

N

-0.64

256.12

0

 

76

K

-1.1

366.25

1

 

97

H

-0.4

334.84

1

 

220

A

0.25

156.55

0

 

271

Q

-0.69

308.35

0

 

326

N

-0.64

256.12

0

 

356

I

0.73

313.43

0

 

371

R

-1.8

421.32

1

 
 

SUM

-3.99

2959.82

3

 
 

MEAN

-0.399

295.982

0.3

 
  1. (example given is CQ-sensitive clone GC03).