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Table 3 Mean physicochemical parameters and drug IC50 values[16] for clones of P. falciparum showing different haplotypes of PfCRT.

From: Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine

clone c1GC03 c2GC03 c3dd2 c4dd2 c5k76I c67g8
mutable residues 72-76 CMNK CMNK CIET CIET CIEI SMNT
mutable residues 72-371 CMNK HAQNIR CMNK HAQNIR CIET HSESTI CIET HSESTI CIEI HSESII SMNT HSQDLR
mean EIS 72-76 -0.275 -0.275 -0.0075 -0.0075 0.22 -0.205
mean EIS 72-371 -0.399 -0.399 -0.102 -0.102 0.08 -0.416
mean SCV 72-76 292.3025 292.3025 264.0275 264.0275 282.7475 251.2875
mean SCV 72-371 295.982 295.982 260.1521 260.1521 275.7521 275.2463
mean CH 72-76 0.25 0.25 -0.25 -0.25 -0.25 0
mean CH 72-371 0.3 0.3 -0.1 -0.1 -0.1 0.1
CQ IC50 nM 27.4 22.9 143.8 147.4 101.7 126.9
DCQ IC50 nM ND 37.7 875.2 1182.2 635.3 649.4
AQ IC50 nM 20.2 18.2 31.6 25.8 28.9 35.8
DAQ IC50 nM ND 45.2 70.2 67.9 54.8 86.2
C-V IC50 nM 27.9 21.8 76.2 71.3 49.4 106.2