Table 3 Mean physicochemical parameters and drug IC50 values[16] for clones of P. falciparum showing different haplotypes of PfCRT.
clone | c1GC03 | c2GC03 | c3dd2 | c4dd2 | c5k76I | c67g8 |
|---|---|---|---|---|---|---|
mutable residues 72-76 | CMNK | CMNK | CIET | CIET | CIEI | SMNT |
mutable residues 72-371 | CMNK HAQNIR | CMNK HAQNIR | CIET HSESTI | CIET HSESTI | CIEI HSESII | SMNT HSQDLR |
mean EIS 72-76 | -0.275 | -0.275 | -0.0075 | -0.0075 | 0.22 | -0.205 |
mean EIS 72-371 | -0.399 | -0.399 | -0.102 | -0.102 | 0.08 | -0.416 |
mean SCV 72-76 | 292.3025 | 292.3025 | 264.0275 | 264.0275 | 282.7475 | 251.2875 |
mean SCV 72-371 | 295.982 | 295.982 | 260.1521 | 260.1521 | 275.7521 | 275.2463 |
mean CH 72-76 | 0.25 | 0.25 | -0.25 | -0.25 | -0.25 | 0 |
mean CH 72-371 | 0.3 | 0.3 | -0.1 | -0.1 | -0.1 | 0.1 |
CQ IC50 nM | 27.4 | 22.9 | 143.8 | 147.4 | 101.7 | 126.9 |
DCQ IC50 nM | ND | 37.7 | 875.2 | 1182.2 | 635.3 | 649.4 |
AQ IC50 nM | 20.2 | 18.2 | 31.6 | 25.8 | 28.9 | 35.8 |
DAQ IC50 nM | ND | 45.2 | 70.2 | 67.9 | 54.8 | 86.2 |
C-V IC50 nM | 27.9 | 21.8 | 76.2 | 71.3 | 49.4 | 106.2 |