Skip to main content

Table 4 Hydrophobicity values (log D) of drugs at pH 5.2 [30], their volume, surface area and number of positive charges.

From: Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine

drug logD5.2 Vol(Å3) (base) surface area (Å2) (base) protons (positive charges)
CQ -3.44 1010 606 2
DCQ -4.61 910 555 2
AQ -1.06 996 568 2
DAQ -2.54 930 554 2
VP 0.59 1340 734 1