Table 5 Changes in physicochemical parameters seen in mutations associated with CQ-resistance in lines of P. falciparum from field and laboratory*.
RESIDUE | mutants | Δ sc charge res-sens | Δ EIS res-sens | Δ SCV Å3 res/sens |
|---|---|---|---|---|
CYS 72 | SER | 0 | -0.30 | 0.834 |
MET 74 | ILE | 0 | 0.47 | 0.957 |
ASN 75 | GLU | -1 | 0.02 | 1.111 |
LYS 76 | THR ILE* ASN* | -1 -1 -1 | 0.92 1.83 0.46 | 0.652 0.855 0.699 |
HIS 97 | GLN | -1 | -0.29 | 0.921 |
ALA 220 | SER | 0 | -0.51 | 1.170 |
GLN 271 | GLU | -1 | 0.07 | 0.923 |
ASN 326 | SER ASP | 0 -1 | 0.38 -0.08 | 0.714 0.907 |
ILE 356 | THR LEU | 0 0 | -0.91 -0.20 | 0.761 1.007 |
ARG 371 | ILE THR | -1 -1 | 2.53 1.62 | 0.744 0.566 |
MEAN (± S.E.) |  | -0.60 (0.13) | 0.40 (0.25) | 0.86 (0.04) |