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Table 5 Changes in physicochemical parameters seen in mutations associated with CQ-resistance in lines of P. falciparum from field and laboratory*.

From: Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine

RESIDUE mutants Δ sc charge res-sens Δ EIS res-sens Δ SCV Å3 res/sens
CYS 72 SER 0 -0.30 0.834
MET 74 ILE 0 0.47 0.957
ASN 75 GLU -1 0.02 1.111
LYS 76 THR ILE* ASN* -1 -1 -1 0.92 1.83 0.46 0.652 0.855 0.699
HIS 97 GLN -1 -0.29 0.921
ALA 220 SER 0 -0.51 1.170
GLN 271 GLU -1 0.07 0.923
ASN 326 SER ASP 0 -1 0.38 -0.08 0.714 0.907
ILE 356 THR LEU 0 0 -0.91 -0.20 0.761 1.007
ARG 371 ILE THR -1 -1 2.53 1.62 0.744 0.566
MEAN (± S.E.)   -0.60 (0.13) 0.40 (0.25) 0.86 (0.04)