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Table 6 For 4 CQ-resistant transfectants the Pearson negative correlations of IC50 value and physicochemical characteristics (R2 values) are shown, and significant results (P ≤ 0.05) on 2-tailed analyses are asterisked.

From: Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine

drug ratio R+/R EIS 72-76 EIS 72-371 SCV 72-76 SCV 72-371
CQ 1.5 0.29 0.11 0.37 0.77
DCQ 1.9 0 0.02 0.02 0.76
AQ 1.4 0.41 0.56 0.35 0.23
DAQ 1.6 0.98* 0.98* 0.96* 0
CQ-VE 2.2 0.97* 0.99* 0.94* 0.01