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Table 6 For 4 CQ-resistant transfectants the Pearson negative correlations of IC50 value and physicochemical characteristics (R2 values) are shown, and significant results (P ≤ 0.05) on 2-tailed analyses are asterisked.

From: Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine

drug

ratio R+/R

EIS 72-76

EIS 72-371

SCV 72-76

SCV 72-371

CQ

1.5

0.29

0.11

0.37

0.77

DCQ

1.9

0

0.02

0.02

0.76

AQ

1.4

0.41

0.56

0.35

0.23

DAQ

1.6

0.98*

0.98*

0.96*

0

CQ-VE

2.2

0.97*

0.99*

0.94*

0.01

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Malaria Journal

ISSN: 1475-2875

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