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Table 7 For 5 or 6 transfectants of varying sensitivity, the Pearson negative correlations of IC50 value and physicochemical characteristics (R2 values) are shown, and significant results (P ≤ 0.05) on 2-tailed analyses are asterisked.

From: Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine

drug ratio R/S EIS 72-76 EIS 72-371 SCV 72-76 SCV 72-371 CH 72-76 CH 72-371
CQ 6.4 0.35 0.30 0.77* 0.95* 0.80* 0.80*
DCQ 31.4 0.28 0.26 0.45 0.93* 0.75* 0.75*
AQ 2.0 0.17 0.08 0.76* 0.47 0.41 0.41
DAQ 1.9 0.01 0.01 0.98* 0.34 0.10 0.10
CQ-VE 4.9 0.04 0.01 0.98* 0.53 0.32 0.32