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Table 7 For 5 or 6 transfectants of varying sensitivity, the Pearson negative correlations of IC50 value and physicochemical characteristics (R2 values) are shown, and significant results (P ≤ 0.05) on 2-tailed analyses are asterisked.

From: Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine

drug

ratio R/S

EIS 72-76

EIS 72-371

SCV 72-76

SCV 72-371

CH 72-76

CH 72-371

CQ

6.4

0.35

0.30

0.77*

0.95*

0.80*

0.80*

DCQ

31.4

0.28

0.26

0.45

0.93*

0.75*

0.75*

AQ

2.0

0.17

0.08

0.76*

0.47

0.41

0.41

DAQ

1.9

0.01

0.01

0.98*

0.34

0.10

0.10

CQ-VE

4.9

0.04

0.01

0.98*

0.53

0.32

0.32