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Table 4 Frequencies and geometric mean levels of IFN-γ responses to PHA, LSA-1 and MSP-1 peptides by age.

From: Interferon-gamma responses to Plasmodium falciparum liver-stage antigen-1 and merozoite-surface protein-1 increase with age in children in a malaria holoendemic area of western Kenya

Condition PHA MSP-1 (aa 20–39) LSA-1, T3
Age (months) No. pos./Tot. (%)a Geo. mean (range)b No. pos./Tot (%) Geo. mean (range) No. pos./Tot (%) Geo. mean (range)
0–12 11/11 (100) 2481.8 (164.9–6206.5) 1/10 (10.0) 12.2 (0–105.5) 0/9 (0.0) 0 (0–0.0)
13–24 12/12 (100) 1859.7 (95.1–3635.4) 1/10 (10.0) 124.6 (0–1245.9) 1/9 (11.1) 71.7 (0–645.2)
25–36 13/13 (100) 2875.7 (547.1–6891.6) 3/11 (27.3) 137.7 (0–1003.4) 4/11 (36.4) 68.6 (0–443.2)
37–48 12/12 (100) 2294.1 (99.8–4254.1) 4/10 (40.0) 203.7 (0–1097) 4/10 (40.0) 217.9 (0–983.5)
P NSc NSd 0.070 NS 0.019 NS
  1. a A positive response was defined as any response ≥ 20 pg/ml above that of unstimulated cell culture supernatants. b Geometric mean cytokine levels in pg/ml. c NS= not significant. P < 0.05 considered significant, as determined by χ2 test for trend across age groups. d P < 0.05 was considered significant as determined by analysis of variance of log-transformed values across age groups.