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Table 5 Frequencies and geometric mean levels of IL-10 responses to PHA, LSA-1 and MSP-1 peptides by age.

From: Interferon-gamma responses to Plasmodium falciparum liver-stage antigen-1 and merozoite-surface protein-1 increase with age in children in a malaria holoendemic area of western Kenya

Condition PHA MSP-1 (aa 20–39) LSA-1, T3
Age (months) No. pos./Tot. (%)a Geo. mean (range)b No. pos./Tot (%) Geo. mean (range) No. pos./Tot (%) Geo. mean (range)
0–12 7/11 (63.6) 241.4 (0–1247.0) 2/10 (20.0) 8.6 (0–48.93) 0/9 (0.0 1.3 (0–11.6)
13–24 9/12 (75.0) 155.6 (2.26–847.5) 3/10 (30.0) 19.4 (0–67.70) 1/9 (11.1) 17.5 (0–125.2)
25–36 10/13 (76.9) 195.8 (0–800.0) 0/11 (0.0) 2.7 (0–11.88) 0/11 (0.0) 1.1 (0–7.8)
37–48 10/12 (83.3) 267.7 (0.02–806.2) 2/10 (20.0) 57.9 (0–44.95) 2/10 (20.0) 16.6 (0–118.4)
P NSc NSd NS NS NS NS
  1. a A positive response was defined as any response ≥ 20 pg/ml above that of unstimulated cell culture supernatants. b Geometric mean cytokine levels in pg/ml. c NS= not significant. P < 0.05 considered significant, as determined by χ2 test for trend across age groups. d P < 0.05 was considered significant as determined by analysis of variance of log-transformed values across age groups.