TY - JOUR AU - Dow, Geoffrey S. PY - 2003 DA - 2003/02/27 TI - Effect of sample size and P-value filtering techniques on the detection of transcriptional changes induced in rat neuroblastoma (NG108) cells by mefloquine JO - Malaria Journal SP - 4 VL - 2 IS - 1 AB - There is no known biochemical basis for the adverse neurological events attributed to mefloquine. Identification of genes modulated by toxic agents using microarrays may provide sufficient information to generate hypotheses regarding their mode of action. However, this utility may be compromised if sample sizes are too low or the filtering methods used to identify differentially expressed genes are inappropriate. SN - 1475-2875 UR - https://doi.org/10.1186/1475-2875-2-4 DO - 10.1186/1475-2875-2-4 ID - Dow2003 ER -